Letter: Chronic active hepatitis induced by nitrofurantoin.

Nitrofurantoin-induced chronic active hepatitis.

BACKGROUND Nitrofurantoin is a commonly prescribed urinary antiseptic. Hepatic injury has been associated with its use. OBJECTIVES To present three patients in whom long-term exposure to the drug resulted in chronic active hepatitis; and to review the epidemiology, clinical immunology, histopathology, pathogenetic features and treatment of previously reported cases. RESULTS Withdrawing nitr...

Pancreatitis induced by nitrofurantoin.

The case of a woman is described who suffered from acute pancreatitis related to the ingestion of low dose nitrofurantoin, as shown by involuntary rechallenge. Because this is only the second case reported in published works, this side effect must be rare and is probably dependent on individual susceptibility.

Chronic Hepatitis/Chronic Active Hepatitis in Dogs

Chronic Active Hepatitis

Our previous observations of highly significant increases in high titre antibodies to measles and rubella in patients with chronic active hepatitis have been extended and it has been shown that these reactions do not occur in other forms of liver disease. Significant increases in antibody titres to cytomegalovirus have also been found in patients with chronic active hepatitis (p<0001) and alcoh...

Autoimmune hepatitis triggered by nitrofurantoin: a case series

INTRODUCTION Drugs can occasionally trigger the onset of autoimmune liver disease. CASE PRESENTATION Three Caucasian women (aged 65, 42 and 74 years old) who were receiving long-term nitrofurantoin as prophylaxis against recurrent urinary tract infections developed hepatitic liver disease. Serological auto-antibody profiles and liver histology appearances were consistent with autoimmune hepat...